The DL380 Gen10 is the best-selling server of its generation and the backbone of the world's 2017-2021 rack rows — twenty-four DDR4 slots on 1st/2nd-gen Xeon Scalable, reaching 3TB with LRDIMMs. In 2026 it sits exactly where this site's value thesis points: a proven platform, an enormous installed base with empty slots, and memory from the affordable half of the shortage.
The QuickSpecs are unusually explicit that speed follows the processor tier, and the rules box preserves the ladder: 2933 MT/s with Platinum and Gold 82xx/62xx, stepping down through 2666 (Gold 52xx) and 2400 (Silver) to 2133 with Bronze. Identify your CPU before paying for grades the socket will downclock — the table's faster modules all work, but the Bronze-equipped box gets no benefit from them.
HPE memory speed by processor (1 and 2 DIMMs per channel): 2933 MT/s with Xeon Platinum/Gold 82xx/62xx, 2666 with Gold 52xx, 2400 with Silver 42xx, 2133 with Bronze 32xx.
1st and 2nd Gen Intel Xeon Scalable; max memory per socket depends on processor (2nd-gen M = 2TB, L = 4.5TB per CPU). Max capacity 3TB with 24x 128GB LRDIMM; RDIMM max 1.54TB with 24x 64GB.
Source: HPE official documentation
Operating speed depends on CPU generation and DIMMs per channel — HPE memory speed by processor (1 and 2 DIMMs per channel): 2933 MT/s with Xeon Platinum/Gold 82xx/62xx, 2666 with Gold 52xx, 2400 with Silver 42xx, 2133 with Bronze 32xx.. Always verify against HPE's QVL for your exact configuration.
| Brand | Module | Capacity | Speed | Type | $/GB | Price | |
|---|---|---|---|---|---|---|---|
| A-Tech | B0BPN414ZJ | 64GB | DDR4-2666 | LRDIMM | $4.31 | $275.96 | Buy → |
| A-Tech | M393A2G40DB0-CPB | 16GB | DDR4-2133 | RDIMM | $4.53 | $72.48 | Buy → |
| Samsung | M393A4K40CB1-CRC | 32GB | DDR4-2400 | RDIMM | $4.84 | $154.94 | Buy → |
| SK Hynix | HMAA8GL7MMR4N | 64GB | DDR4-2400 | RDIMM | $4.92 | $314.95 | Buy → |
| A-Tech | B0BPN4FLDX | 32GB | DDR4-2666 | RDIMM | $5.02 | $160.53 | Buy → |
| Micron | MTA36ASF4G72PZ | 32GB | DDR4-2666 | RDIMM | $5.47 | $175.00 | Buy → |
| A-Tech | B083Q3F5DX | 32GB | DDR4-2400 | RDIMM | $5.69 | $182.12 | Buy → |
| Samsung | M393A2G40EB1-CPB | 16GB | DDR4-2133 | RDIMM | $5.76 | $92.18 | Buy → |
| Samsung | M393A8K40B22-CWD | 64GB | DDR4-2666 | RDIMM | $6.23 | $399.00 | Buy → |
| Supermicro | B07DFLTWN3 | 64GB | DDR4-2666 | LRDIMM | $6.23 | $399.00 | Buy → |
| SK Hynix | HMA84GR7CJR4N-VK | 32GB | DDR4-2666 | RDIMM | $6.72 | $214.94 | Buy → |
| Samsung | M393A4K40CB2-CTD | 32GB | DDR4-2666 | RDIMM | $6.81 | $218.01 | Buy → |
| A-Tech | B0C2FML23M | 64GB | DDR4-2933 | RDIMM | $8.06 | $515.96 | Buy → |
| A-Tech | KTD-PE429 | 64GB | DDR4-2933 | RDIMM | $8.28 | $530.11 | Buy → |
| Samsung | M393A2K43CB2-CTD8Q | 16GB | DDR4-2666 | RDIMM | $8.37 | $133.99 | Buy → |
| A-Tech | B0BPN4L74H | 32GB | DDR4-2933 | RDIMM | $9.11 | $291.60 | Buy → |
| Kingston | KSM24RD4/32MEI | 32GB | DDR4-2400 | RDIMM | $9.22 | $295.10 | Buy → |
| A-Tech | B0CGJFB4TG | 32GB | DDR4-2933 | RDIMM | $9.33 | $298.70 | Buy → |
| SK Hynix | HMAA8GR7AJR4N-XN | 64GB | DDR4-3200 (runs at up to 2933 here) | RDIMM | $9.36 | $599.00 | Buy → |
| Samsung | M393A8G40BB4-CWE | 64GB | DDR4-3200 (runs at up to 2933 here) | RDIMM | $9.98 | $639.00 | Buy → |
| A-Tech | MTA36ASF8G72PZ | 64GB | DDR4-3200 (runs at up to 2933 here) | RDIMM | $10.56 | $675.95 | Buy → |
| Samsung | M393A2K43BB1-CTD6Q | 16GB | DDR4-2666 | RDIMM | $10.97 | $175.49 | Buy → |
| Kingston | KTD-PE426 | 32GB | DDR4-2666 | RDIMM | $11.09 | $354.96 | Buy → |
| Crucial | B017UGKB32 | 16GB | DDR4-2400 | RDIMM | $11.25 | $179.99 | Buy → |
| Samsung | M393A2K43DB2-CTD6Y | 16GB | DDR4-2666 | RDIMM | $12.19 | $194.99 | Buy → |
| Samsung | M393A8G40AB2-CWE | 64GB | DDR4-3200 (runs at up to 2933 here) | RDIMM | $12.48 | $799.00 | Buy → |
Each scenario is priced from the cheapest compatible in-stock module at that capacity, at the timestamp above. Configurations never exceed the platform's 24 DIMM slots. Populate channels per the OEM rules below for full bandwidth.
Mixing of RDIMM and LRDIMM memory is not supported. Intel Optane PMem for HPE is only supported with select 2nd-gen Xeon Scalable processors; HPE NVDIMMs are only supported on 1st-gen processors and can only be mixed with RDIMMs.
Speed behavior on this platform: HPE memory speed by processor (1 and 2 DIMMs per channel): 2933 MT/s with Xeon Platinum/Gold 82xx/62xx, 2666 with Gold 52xx, 2400 with Silver 42xx, 2133 with Bronze 32xx. Faster-rated modules from the table above are safe — they operate at the platform's supported speed for your configuration rather than their label speed.
Paraphrased from HPE's official documentation. Anything the manual does not state is omitted here rather than guessed.
The Gen10 buying sequence: read your CPU tier off the QuickSpecs ladder (Platinum/Gold 82xx/62xx → 2933; 52xx → 2666; Silver → 2400; Bronze → 2133), then buy the cheapest per-GB grade at or above it from the live table — higher grades downclock harmlessly, and in the current pull-rich market the 2666 and 2933 tiers frequently invert on price.
Respect the type wall: RDIMM boxes stay RDIMM, LRDIMM boxes stay LRDIMM, and the exotic options (Optane PMem, NVDIMM) carry processor-generation dependencies the QuickSpecs spell out. For the ninety-percent case — filling empty slots with matched 16/32/64GB RDIMMs — this platform is as easy as server memory gets, and nearly as cheap as it gets in 2026.
Every specification in the rules box above was verified against the HPE document linked beneath it before this page went live — nothing is inferred from forum lore or reseller listings, and any field the document does not state is simply absent here rather than guessed. The compatibility table applies those verified rules mechanically to our tracked module catalog: generation must match, the module type must appear in the platform's allowed list, speed must meet the documented floor, and per-DIMM capacity must respect the stated maximum. What survives that filter is sorted by live $/GB — computed against true 1024-based capacities — and refreshed on the same rolling cycle as every price on this site.
Two honest limits worth stating. First, our catalog tracks the retail module market, not HPE's option-part universe — a module absent from the table is not declared incompatible, merely untracked; the rules box tells you what any candidate must satisfy. Second, a compatibility table is not a QVL: HPE validates specific part numbers against specific configurations, and the disclaimer above the table is not boilerplate but the actual final step. Use this page to find the market's honest price for compliant memory; use the vendor's QVL to bless the exact part before a production order.
Gen10 DL380s serve two constituencies in 2026. Enterprise fleets on extended lifecycles keep feeding them because the platform still clears the workload bar and DDR4 is the cheap way to keep it clearing — doubling memory costs a small fraction of a Gen11 replacement. And the off-lease wave has made the DL380 Gen10 a homelab heavyweight: huge slot count, iLO management, and street prices that compete with the Dell R740 it fought all generation.
The RDIMM-versus-LRDIMM fork matters here more than most platforms: HPE forbids mixing them, RDIMMs top out at 1.54TB across the box, and the 3TB headline requires 128GB LRDIMMs throughout. Most buyers never approach either ceiling — but whichever type is in the slots today is the type every future module must match, so check before ordering from the table.
HPE's documentation puts the platform maximum at 3TB across 24 DIMM slots, with single modules supported up to 128GB. Reaching the maximum requires the largest supported DIMM in every slot — most real upgrades target far less, which is what the live scenarios above price.
DDR4 RDIMM and LRDIMM at 2133 to 2933 MT/s, per HPE's documentation. Consumer non-ECC and XMP/EXPO kits are not supported — every module in the table above is a verified ECC server part of the correct type.
HPE's stated rules: Mixing of RDIMM and LRDIMM memory is not supported. Intel Optane PMem for HPE is only supported with select 2nd-gen Xeon Scalable processors; HPE NVDIMMs are only supported on 1st-gen processors and can only be mixed with RDIMMs. Mixed speeds, where allowed, run at the slowest module's speed — buying identical part numbers per channel remains the safe pattern.
Yes — modules rated above 2933 MT/s downclock to the platform's supported speed and run normally, which is why the table marks them "runs at up to 2933 here". Modules rated below 2133 MT/s are excluded from the table because HPE does not list them as supported.
8× 64GB fills 512GB and leaves 16 of the 24 slots free for later growth. Fewer, larger DIMMs preserve expansion room; more, smaller DIMMs are sometimes cheaper per GB — the live table above lets you price both routes at today's numbers.
Used and refurbished DDR4 ECC is a rational choice for this platform — DRAM has no meaningful wear mechanism, and tested pulls from decommissioned fleets often undercut new pricing substantially. Run memtest86+ on arrival and watch ECC counters for the first weeks. For production fleets, new modules with warranty remain the conservative default.
Whatever your processor tier supports: 2933 MT/s on Platinum/Gold 82xx/62xx, 2666 on Gold 52xx, 2400 on Silver 42xx, 2133 on Bronze 32xx, per the QuickSpecs. Faster-rated modules downclock to that ceiling — so buy the cheapest per-GB grade at or above it.