The ML350 Gen10 is HPE's big tower — a full dual-socket Xeon Scalable platform with twenty-four DDR4 slots, wrapped in a chassis quiet enough for the office it usually serves. It is what businesses without server rooms buy when they need server-room capability, and its memory story is the friendly side of 2026: DDR4 grades with deep supply and honest prices.
The QuickSpecs' speed ladder is preserved in the rules box: 2933 MT/s at one DIMM per channel on Platinum 8200 and Gold 6200 silicon (2666 at 2DPC), stepping down through 2400 on Silver to 2133 on Bronze. As across the Gen10 line, RDIMM and LRDIMM never mix, and the processor — not the module — sets the operating speed.
Platinum 8200 / Gold 6200 series support 6-channel DDR4 at 2933 MT/s at 1DPC and 2666 at 2DPC; Silver SKUs run 2400 and Bronze 3206R runs 2133. Maximum memory by socket is limited by processor selection.
Intel Xeon Scalable incl. 2nd-gen refresh; Platinum 8200/Gold 6200 provide up to 1TB memory per socket (more on select SKUs). Max 3TB with 24x 128GB LRDIMM; RDIMM max 1.5TB with 24x 64GB. Tower form factor.
Source: HPE official documentation
Operating speed depends on CPU generation and DIMMs per channel — Platinum 8200 / Gold 6200 series support 6-channel DDR4 at 2933 MT/s at 1DPC and 2666 at 2DPC; Silver SKUs run 2400 and Bronze 3206R runs 2133. Maximum memory by socket is limited by processor selection.. Always verify against HPE's QVL for your exact configuration.
| Brand | Module | Capacity | Speed | Type | $/GB | Price | |
|---|---|---|---|---|---|---|---|
| A-Tech | B0BPN414ZJ | 64GB | DDR4-2666 | LRDIMM | $4.31 | $275.96 | Buy → |
| A-Tech | M393A2G40DB0-CPB | 16GB | DDR4-2133 | RDIMM | $4.53 | $72.48 | Buy → |
| Samsung | M393A4K40CB1-CRC | 32GB | DDR4-2400 | RDIMM | $4.84 | $154.94 | Buy → |
| SK Hynix | HMAA8GL7MMR4N | 64GB | DDR4-2400 | RDIMM | $4.92 | $314.95 | Buy → |
| A-Tech | B0BPN4FLDX | 32GB | DDR4-2666 | RDIMM | $5.02 | $160.53 | Buy → |
| Micron | MTA36ASF4G72PZ | 32GB | DDR4-2666 | RDIMM | $5.47 | $175.00 | Buy → |
| A-Tech | B083Q3F5DX | 32GB | DDR4-2400 | RDIMM | $5.69 | $182.12 | Buy → |
| Samsung | M393A2G40EB1-CPB | 16GB | DDR4-2133 | RDIMM | $5.76 | $92.18 | Buy → |
| Samsung | M393A8K40B22-CWD | 64GB | DDR4-2666 | RDIMM | $6.23 | $399.00 | Buy → |
| Supermicro | B07DFLTWN3 | 64GB | DDR4-2666 | LRDIMM | $6.23 | $399.00 | Buy → |
| SK Hynix | HMA84GR7CJR4N-VK | 32GB | DDR4-2666 | RDIMM | $6.72 | $214.94 | Buy → |
| Samsung | M393A4K40CB2-CTD | 32GB | DDR4-2666 | RDIMM | $6.81 | $218.01 | Buy → |
| A-Tech | B0C2FML23M | 64GB | DDR4-2933 | RDIMM | $8.06 | $515.96 | Buy → |
| A-Tech | KTD-PE429 | 64GB | DDR4-2933 | RDIMM | $8.28 | $530.11 | Buy → |
| Samsung | M393A2K43CB2-CTD8Q | 16GB | DDR4-2666 | RDIMM | $8.37 | $133.99 | Buy → |
| A-Tech | B0BPN4L74H | 32GB | DDR4-2933 | RDIMM | $9.11 | $291.60 | Buy → |
| Kingston | KSM24RD4/32MEI | 32GB | DDR4-2400 | RDIMM | $9.22 | $295.10 | Buy → |
| A-Tech | B0CGJFB4TG | 32GB | DDR4-2933 | RDIMM | $9.33 | $298.70 | Buy → |
| SK Hynix | HMAA8GR7AJR4N-XN | 64GB | DDR4-3200 (runs at up to 2933 here) | RDIMM | $9.36 | $599.00 | Buy → |
| Samsung | M393A8G40BB4-CWE | 64GB | DDR4-3200 (runs at up to 2933 here) | RDIMM | $9.98 | $639.00 | Buy → |
| A-Tech | MTA36ASF8G72PZ | 64GB | DDR4-3200 (runs at up to 2933 here) | RDIMM | $10.56 | $675.95 | Buy → |
| Samsung | M393A2K43BB1-CTD6Q | 16GB | DDR4-2666 | RDIMM | $10.97 | $175.49 | Buy → |
| Kingston | KTD-PE426 | 32GB | DDR4-2666 | RDIMM | $11.09 | $354.96 | Buy → |
| Crucial | B017UGKB32 | 16GB | DDR4-2400 | RDIMM | $11.25 | $179.99 | Buy → |
| Samsung | M393A2K43DB2-CTD6Y | 16GB | DDR4-2666 | RDIMM | $12.19 | $194.99 | Buy → |
| Samsung | M393A8G40AB2-CWE | 64GB | DDR4-3200 (runs at up to 2933 here) | RDIMM | $12.48 | $799.00 | Buy → |
Each scenario is priced from the cheapest compatible in-stock module at that capacity, at the timestamp above. Configurations never exceed the platform's 24 DIMM slots. Populate channels per the OEM rules below for full bandwidth.
Mixing of RDIMM and LRDIMM memory is not supported, and the maximum memory by socket is limited by the processor selection.
Speed behavior on this platform: Platinum 8200 / Gold 6200 series support 6-channel DDR4 at 2933 MT/s at 1DPC and 2666 at 2DPC; Silver SKUs run 2400 and Bronze 3206R runs 2133. Maximum memory by socket is limited by processor selection. Faster-rated modules from the table above are safe — they operate at the platform's supported speed for your configuration rather than their label speed.
Paraphrased from HPE's official documentation. Anything the manual does not state is omitted here rather than guessed.
The ML350 purchase is usually a one-shot: a business fills its tower once mid-life and never thinks about memory again. Make the shot count — even counts across both sockets if the second CPU is present, the 2933-or-below grade your processor tier actually runs, and enough headroom that next year's workload does not reopen the case. The scenarios above price the sensible rungs from live listings.
Office placement earns one quality note: the ML350 runs quiet precisely because its thermals are relaxed, and relaxed thermals are kind to memory — including the tested pulls this generation's decommissioning wave supplies cheaply. Match part numbers per channel and the tower will serve out its long office life without a beep.
Every specification in the rules box above was verified against the HPE document linked beneath it before this page went live — nothing is inferred from forum lore or reseller listings, and any field the document does not state is simply absent here rather than guessed. The compatibility table applies those verified rules mechanically to our tracked module catalog: generation must match, the module type must appear in the platform's allowed list, speed must meet the documented floor, and per-DIMM capacity must respect the stated maximum. What survives that filter is sorted by live $/GB — computed against true 1024-based capacities — and refreshed on the same rolling cycle as every price on this site.
Two honest limits worth stating. First, our catalog tracks the retail module market, not HPE's option-part universe — a module absent from the table is not declared incompatible, merely untracked; the rules box tells you what any candidate must satisfy. Second, a compatibility table is not a QVL: HPE validates specific part numbers against specific configurations, and the disclaimer above the table is not boilerplate but the actual final step. Use this page to find the market's honest price for compliant memory; use the vendor's QVL to bless the exact part before a production order.
ML350 owners are the small-business consolidators: one tower running the hypervisor that runs everything, upgraded the day the accounting package's new version or one more line-of-business VM tips the memory balance. The friendly math — 64GB to 256GB of DDR4 at live prices — is usually the cheapest infrastructure fix these businesses will encounter all year.
The tower also earns a homelab following for the same reason the T640 does: rack capability without rack acoustics. Used-market buyers should apply the generation's standard check — CPU tier sets the speed ceiling, so a Silver-equipped unit gains nothing from 2933-rated modules the socket will run at 2400.
HPE's documentation puts the platform maximum at 3TB across 24 DIMM slots, with single modules supported up to 128GB. Reaching the maximum requires the largest supported DIMM in every slot — most real upgrades target far less, which is what the live scenarios above price.
DDR4 RDIMM and LRDIMM at 2133 to 2933 MT/s, per HPE's documentation. Consumer non-ECC and XMP/EXPO kits are not supported — every module in the table above is a verified ECC server part of the correct type.
HPE's stated rules: Mixing of RDIMM and LRDIMM memory is not supported, and the maximum memory by socket is limited by the processor selection. Mixed speeds, where allowed, run at the slowest module's speed — buying identical part numbers per channel remains the safe pattern.
Yes — modules rated above 2933 MT/s downclock to the platform's supported speed and run normally, which is why the table marks them "runs at up to 2933 here". Modules rated below 2133 MT/s are excluded from the table because HPE does not list them as supported.
8× 64GB fills 512GB and leaves 16 of the 24 slots free for later growth. Fewer, larger DIMMs preserve expansion room; more, smaller DIMMs are sometimes cheaper per GB — the live table above lets you price both routes at today's numbers.
Used and refurbished DDR4 ECC is a rational choice for this platform — DRAM has no meaningful wear mechanism, and tested pulls from decommissioned fleets often undercut new pricing substantially. Run memtest86+ on arrival and watch ECC counters for the first weeks. For production fleets, new modules with warranty remain the conservative default.
The common consolidation stack — domain services, file serving, two or three application VMs, backup — lives comfortably in 64-192GB, far below the platform's 3TB ceiling. Check the live table for today's cheapest compliant 16GB or 32GB part and buy in even counts per the population rules.