The DL380 Gen11 is HPE's volume 2U for the DDR5 era and the direct rival to Dell's R760: thirty-two DIMM slots across two 4th- or 5th-gen Xeon sockets, reaching 8TB in the right chassis. The QuickSpecs carry a configuration subtlety worth knowing before you count slots: the full 32-DIMM population applies to 8SFF and 16SFF chassis only — 24SFF configurations are limited to sixteen DIMMs, which halves the memory ceiling of the storage-densest variant.
HPE's rules for the platform, quoted in the box below, follow the DDR5-generation pattern: DIMMs in even quantities, no mixing of 3DS and non-3DS parts, and x4-only when Memory Fault Tolerance is in play. The table below holds our tracked catalog to those rules at the platform's operating floor, sorted by live $/GB — the neutral version of the answer HPE's configurator sells.
Max memory speed is limited by processor selection: 5th Gen Xeon SKUs list DDR5 at 5600/5200/4800 MT/s; DDR5-4800 kits are only supported with 4th Gen Xeon Scalable and run 4800 MT/s at 1DPC, 4400 MT/s at 2DPC.
4th and 5th Gen Intel Xeon Scalable; up to 4TB max memory per processor; mixing of two different processor models is not allowed.
Source: HPE official documentation
Operating speed depends on CPU generation and DIMMs per channel — Max memory speed is limited by processor selection: 5th Gen Xeon SKUs list DDR5 at 5600/5200/4800 MT/s; DDR5-4800 kits are only supported with 4th Gen Xeon Scalable and run 4800 MT/s at 1DPC, 4400 MT/s at 2DPC.. Always verify against HPE's QVL for your exact configuration.
| Brand | Module | Capacity | Speed | Type | $/GB | Price | |
|---|---|---|---|---|---|---|---|
| V-Color | B0GYCQNYQ6 | 256GB | DDR5-4800 | RDIMM | $25.78 | $6599.99 | Buy → |
| Samsung | M321R2GA3BB6-CQK | 16GB | DDR5-4800 | RDIMM | $28.13 | $450.00 | Buy → |
| Samsung | M321R4GA3BB6-CQK | 32GB | DDR5-4800 | RDIMM | $29.00 | $928.00 | Buy → |
| A-Tech | M321R4GA0PB0-CWM | 32GB | DDR5-5600 | RDIMM | $29.18 | $933.68 | Buy → |
| Samsung | M321R8GA0BB0-CQK | 64GB | DDR5-4800 | RDIMM | $30.55 | $1955.00 | Buy → |
| NEMIX | MTC20F2085S1RC48BR | 32GB | DDR5-4800 | RDIMM | $30.90 | $988.88 | Buy → |
| SK Hynix | HMCG88AEBRA168N | 32GB | DDR5-4800 | RDIMM | $31.13 | $996.26 | Buy → |
| A-Tech | B0DMC1VFNS | 96GB | DDR5-4800 | RDIMM | $31.15 | $2989.99 | Buy → |
| Samsung | M321RYGA0BB0-CQK | 96GB | DDR5-4800 | RDIMM | $31.15 | $2989.99 | Buy → |
| SK Hynix | HMCT04MEERA132N | 128GB | DDR5-4800 | RDIMM | $31.25 | $3999.99 | Buy → |
| Kingston | KSM56R46BD4PMI | 64GB | DDR5-5600 | RDIMM | $32.25 | $2064.00 | Buy → |
| Kingston | KSM56E46BD8KM | 48GB | DDR5-5600 | RDIMM | $33.33 | $1599.99 | Buy → |
| NEMIX | MTC10F1084S1RC56BR | 16GB | DDR5-5600 | RDIMM | $33.93 | $542.88 | Buy → |
| V-Color | B0GYCHJPHZ | 256GB | DDR5-6400 (runs at up to 5600 here) | RDIMM | $34.06 | $8719.99 | Buy → |
| A-Tech | B0DYR9JXRH | 64GB | DDR5-6400 (runs at up to 5600 here) | RDIMM | $34.29 | $2194.49 | Buy → |
| Micron | MTC40F2046S1RC56BD2 | 64GB | DDR5-5600 | RDIMM | $37.50 | $2399.99 | Buy → |
| NEMIX | MTC40F204WS1RC56BB2R | 96GB | DDR5-5600 | RDIMM | $37.50 | $3599.99 | Buy → |
| NEMIX | MTC40F204WS1RC64BC1R | 96GB | DDR5-6400 (runs at up to 5600 here) | RDIMM | $38.54 | $3699.99 | Buy → |
| NEMIX | MTC40F204WS1RC64BR | 96GB | DDR5-6400 (runs at up to 5600 here) | RDIMM | $38.54 | $3699.99 | Buy → |
| Kingston | KSM56R46BD8PMI | 32GB | DDR5-5600 | RDIMM | $44.50 | $1424.00 | Buy → |
Each scenario is priced from the cheapest compatible in-stock module at that capacity, at the timestamp above. Configurations never exceed the platform's 32 DIMM slots. Populate channels per the OEM rules below for full bandwidth.
Memory should be installed in even quantities of DIMMs, and mixing of 3DS and non-3DS memory is not supported. If Memory Fault Tolerance is selected, only x4 memory options can be used. The 32-DIMM (8TB) population applies only to 8SFF/16SFF chassis; 24SFF configurations are limited to 16 DIMMs.
Speed behavior on this platform: Max memory speed is limited by processor selection: 5th Gen Xeon SKUs list DDR5 at 5600/5200/4800 MT/s; DDR5-4800 kits are only supported with 4th Gen Xeon Scalable and run 4800 MT/s at 1DPC, 4400 MT/s at 2DPC. Faster-rated modules from the table above are safe — they operate at the platform's supported speed for your configuration rather than their label speed.
Paraphrased from HPE's official documentation. Anything the manual does not state is omitted here rather than guessed.
Buy against your chassis first (24SFF boxes cap at sixteen DIMMs), your CPU generation second (4800-grade for 4th-gen, the 5600 tier only paying off on 5th-gen), and the live table third. HPE's even-quantities rule and the 3DS/non-3DS wall mean orders arrive as uniform sets — price the set, not the stick, and use the scenarios above as the baseline the quote has to beat.
For Memory Fault Tolerance shops, the x4-only constraint quietly narrows the table: check the organization column on module detail pages before committing a fleet order. And as everywhere in DDR5-land, the per-module 90-day charts are the timing tool — Gen11 memory line items are large enough that catching a 10% dip on sixteen modules pays for the patience.
Every specification in the rules box above was verified against the HPE document linked beneath it before this page went live — nothing is inferred from forum lore or reseller listings, and any field the document does not state is simply absent here rather than guessed. The compatibility table applies those verified rules mechanically to our tracked module catalog: generation must match, the module type must appear in the platform's allowed list, speed must meet the documented floor, and per-DIMM capacity must respect the stated maximum. What survives that filter is sorted by live $/GB — computed against true 1024-based capacities — and refreshed on the same rolling cycle as every price on this site.
Two honest limits worth stating. First, our catalog tracks the retail module market, not HPE's option-part universe — a module absent from the table is not declared incompatible, merely untracked; the rules box tells you what any candidate must satisfy. Second, a compatibility table is not a QVL: HPE validates specific part numbers against specific configurations, and the disclaimer above the table is not boilerplate but the actual final step. Use this page to find the market's honest price for compliant memory; use the vendor's QVL to bless the exact part before a production order.
DL380 Gen11 buyers are running the standard mid-life density play: the platform went in with channels half-fed against a launch budget, and now VM sprawl or an in-memory tier wants the rest. Because HPE validates even-quantity populations balanced across processors, upgrades arrive in planned sets — and at DDR5 prices, the difference between the cheapest and dearest compliant module in the live table, multiplied by sixteen, is real money.
The chassis-variant ceiling deserves a second mention for capacity planners: if the fleet standardized on 24SFF units for drive density, the memory roadmap tops out at sixteen DIMMs per box. Fewer, larger modules become the growth path, which shifts the buying decision toward the 64GB and 96GB tiers the price index tracks daily.
HPE's documentation puts the platform maximum at 8TB across 32 DIMM slots, with single modules supported up to 256GB. Reaching the maximum requires the largest supported DIMM in every slot — most real upgrades target far less, which is what the live scenarios above price.
DDR5 RDIMM and 3DS at 4400 to 5600 MT/s, per HPE's documentation. Consumer non-ECC and XMP/EXPO kits are not supported — every module in the table above is a verified ECC server part of the correct type.
HPE's stated rules: Memory should be installed in even quantities of DIMMs, and mixing of 3DS and non-3DS memory is not supported. If Memory Fault Tolerance is selected, only x4 memory options can be used. The 32-DIMM (8TB) population applies only to 8SFF/16SFF chassis; 24SFF configurations are limited to 16 DIMMs. Mixed speeds, where allowed, run at the slowest module's speed — buying identical part numbers per channel remains the safe pattern.
Yes — modules rated above 5600 MT/s downclock to the platform's supported speed and run normally, which is why the table marks them "runs at up to 5600 here". Modules rated below 4400 MT/s are excluded from the table because HPE does not list them as supported.
8× 64GB fills 512GB and leaves 24 of the 32 slots free for later growth. Fewer, larger DIMMs preserve expansion room; more, smaller DIMMs are sometimes cheaper per GB — the live table above lets you price both routes at today's numbers.
For DDR5 platforms like this one there is effectively no refurbished market yet — the fleets that would feed it are still in service. Buy new, verify the part against HPE's QVL, and use each module's 90-day price chart (linked in the table) to time the purchase.
Check your chassis: HPE's QuickSpecs state the 32-DIMM (8TB) population applies to 8SFF/16SFF configurations, while 24SFF chassis are limited to sixteen DIMMs. The drive-densest variant trades memory ceiling for bays — larger per-DIMM capacities are its growth path.