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HPE ProLiant ML350 Gen10 Hard Drive: Your Cage Decides SAS or SATA

Prices checked: · Published: · Price tracking since 5 November 2026

Quick answer

Check your chassis first. The ML350 Gen10 tower comes as 8 SFF hot-plug (upgradeable to 24 SFF), 4 LFF hot-plug or 4 LFF non-hot-plug, and the LFF chassis can grow to 8 or 12 bays. Hot-plug cages take SAS or SATA; the non-hot-plug LFF version takes SATA only. HPE's QuickSpecs list LFF drives up to 14 TB.

HPE ML350 Gen10 hard drive cages: hot-plug or non-hot-plug

The ML350 Gen10 is a 4U tower that can be converted for a rack. HPE built it in three drive chassis: 8 SFF (2.5-inch) hot-plug, 4 LFF (3.5-inch) hot-plug and 4 LFF non-hot-plug. Which of the three you own decides the interface you can buy.

FeatureHot-plug cagesNon-hot-plug LFF chassis
Starting layout8 SFF or 4 LFF4 LFF
ExpansionSFF to 24 drives; LFF to 8 or 12 with LFF cage kits8 or 12 LFF with LFF NHP cage kits
Hard drive interfacesSAS or SATASATA only

HPE's note on the non-hot-plug version is one line: the NHP LFF SKU supports SATA hard disk drives only. A SAS drive is the wrong buy for that server, however well it fits the bay. The hot-plug cages are listed as SAS/SATA, so either interface goes there.

HPE ships the server with no hard drives as standard, so the choice is yours for every bay, and on a non-hot-plug chassis grown to 12 LFF that means twelve SATA drives. If you are not sure which chassis you have, the QuickSpecs identify the non-hot-plug one by its LFF NHP cage, so look at the cage itself or the server's original configuration before you order.

HPE ProLiant ML350 Gen10 hard drive sizes

HPE's QuickSpecs give maximum internal storage for hot-plug LFF SAS and for hot-plug LFF SATA as 168 TB each, from twelve 14 TB drives, and for hot-plug SFF SAS as 48 TB, from twenty-four 2 TB drives. Those are HPE's configuration examples. HPE's revision notes record the maximum being updated with the 14 TB drives.

The version history we read ends at version 14, dated 3 June 2019, and HPE has marked the document RETIRED. So 14 TB is the largest size we found for this server in HPE's list, not a hardware limit, and we have not found an HPE document that says larger drives work or fail. HPE's two 14 TB midline helium options, one SAS 12G and one SATA 6G, both carry Digitally Signed Firmware in their names:

3.5-inch SAS drives for the ML350 Gen10 hot-plug LFF cages

Only a hot-plug LFF server should look at this table: a non-hot-plug ML350 Gen10 cannot use SAS. Like the two tables after it, it holds maker-branded drives and stops at 14 TB, a cap we set at the largest size in HPE's list rather than a limit HPE states. It shows up to 24 drives in stock on Amazon.co.uk, ranked by price per terabyte in pounds inc VAT. It holds 24 listings right now, the lowest at £24.75/TB.

3.5-inch SAS enterprise drives up to 14 TB on Amazon.co.uk, lowest £/TB first

Product
Part number
Capacity
Interface
Recording
£/TB inc VAT
Condition
Price (inc VAT)
Buy on Amazon
Synology HAS5300 HAS5300-8T 8 TB Hard DriveHAS5300-8T8 TBSASnot sourced£24.75/TBUsedSeller: YMISUPPLY£198.00£198.00Buy on Amazon
HGST HUS724030ALS640 Ultrastar 7K4000 InternalHUS724030ALS6403 TBSASnot sourced£30.00/TBUsedSeller: ServerPartsIT£89.99£89.99Buy on Amazon
Toshiba MG07SCA Series MG07SCA12TE 12TB 512e SAS Hard DriveMG07SCA12TE12 TBSASnot sourced£31.25/TBNewSeller: TeknoBits Ltd.£375.00£375.00Buy on Amazon
HGST Ultrastar 7K4000 HUS724030ALS640 Hard DriveHUS724030ALS6403 TBSASnot sourced£31.66/TBUsedSeller: ServerPartsIT£94.99£94.99Buy on Amazon
Synology 3.5' SAS HDD 8TBHAS5300-8T8 TBSASnot sourced£34.75/TBUsedSeller: YMISUPPLY£278.00£278.00Buy on Amazon
Seagate Exos X10 Enterprise Hard Drive ST10000NM0096 10 TBST10000NM009610 TBSASnot sourced£35.75/TBNewSeller: Miragetek IT Store£357.54£357.54Buy on Amazon
WESTERN DIGITAL ULTRASTAR DC HC310 HUS726T6TAL5204 3.5" 6000 GB SAS Black0B360476 TBSASnot sourced£36.48/TBNewSeller: 88 TECH co uk£218.90£218.90Buy on Amazon
Seagate Enterprise Exos X16 3.5" 10000GB SASST10000NM002G10 TBSASnot sourced£36.67/TBNewSeller: Miragetek IT Store£366.65£366.65Buy on Amazon
HGST ULTRASTAR HE8 8TB 3.5IN HUH728080AL5200 SAS ULTRAHUH728080AL52008 TBSASnot sourced£37.50/TBUsedSeller: ServerPartsIT£299.99£299.99Buy on Amazon
Synology HAS5300 12TBHAS5300-12T12 TBSASnot sourced£37.90/TBNewSeller: cønrad£454.85£454.85Buy on Amazon
Seagate ST4000NM0025ST4000NM00254 TBSASnot sourced£40.84/TBNewSeller: 88 TECH co uk£163.35£163.35Buy on Amazon
HGST 0B360470B360476 TBSASnot sourced£43.08/TBNewSeller: 88 TECH co uk£258.50£258.50Buy on Amazon
MG07SCA14TE 14TB Toshiba SAS 256MB 3.5 Inch 7200 RPM Enterprise HDD for Dell...MG07SCA14TE14 TBSASnot sourced£44.80/TBNewSeller: YUMEZ£627.23£627.23Buy on Amazon
Seagate Exos 7E8 ST4000NM0095ST4000NM00954 TBSASnot sourced£45.00/TBUsedSeller: ServerPartsIT£179.99£179.99Buy on Amazon
HGST Ultrastar 7 K6000 4TB HDD 7200RPM SAS 128MB Cache 24x7 Internal 8.9 cm/...HUS726040ALS2104 TBSASnot sourced£46.15/TBUsedSeller: SIMPLETEK-L'elettronica-low-cost£184.60£184.60Buy on Amazon
Seagate Exos X16ST6000NM00956 TBSASnot sourced£48.17/TBNewSeller: HYT GLOBAL£289.00£289.00Buy on Amazon
HGST Ultrastar 7K4000 4TB 3.5" 7200 RPM SAS 64MB Cache Internal Enterprise H...HUS724040ALS6404 TBSASnot sourced£48.80/TBNewSeller: BRIGHTNESS ONLINE£195.18£195.18Buy on Amazon
HGST HUH721010AL4200 Ultrastar HE10HUH721010AL420010 TBSASnot sourced£48.88/TBNewSeller: 88 TECH co uk£488.75£488.75Buy on Amazon
Seagate Enterprise Capacity 3.5 4TB HDD 7200RPM SAS 128 MB Cache/8.9 cm 3.5...ST4000NM01254 TBSASnot sourced£49.25/TBNewSeller: Maxnet24£197.00£197.00Buy on Amazon
HGST (WESTERN DIGITAL) HUS726T4TAL5204 3.5in 4000GB 256MB 7200RPM SAS ULTRA 512E0B360484 TBSASnot sourced£53.00/TBNewSeller: PCBOOST£211.99£211.99Buy on Amazon
Seagate Exos 7E10 4TB Internal Hard Drive HDDST4000NM005B4 TBSASnot sourced£55.50/TBUsedSeller: Tannas LTD£222.00£222.00Buy on Amazon
HGST Ultrastar 7K6000 6TB SAS 12G 6000 3.5 Internal Bare/OEM DriveHUS726060AL52106 TBSASnot sourced£56.50/TBNewSeller: Acı Store£338.98£338.98Buy on Amazon
Toshiba MG10 10 TBMG10SDA10TE10 TBSASnot sourced£59.01/TBNewSeller: The Full-Cart£590.13£590.13Buy on Amazon
HGST Ultrastar DC HC3100B35919-CR4 TBSASnot sourced£59.40/TBUsedSeller: ServerPartsIT£237.60£237.60Buy on Amazon

n/s = we could not read that value from the listing. Prices are in pounds sterling and include VAT.

3.5-inch SATA drives for any ML350 Gen10 LFF cage

SATA is the one interface every LFF cage on this server accepts, hot-plug or not, so this is the table for a non-hot-plug owner. It holds 24 listings right now, the lowest at £22.50/TB.

3.5-inch SATA enterprise drives up to 14 TB on Amazon.co.uk, lowest £/TB first

Product
Part number
Capacity
Interface
Recording
£/TB inc VAT
Condition
Price (inc VAT)
Buy on Amazon
HGST Ultrastar 6Tb 6144Gb Serial Ata Internal Hard DriveHUS726060ALE6106 TBSATAnot sourced£22.50/TBUsedSeller: smart sm solutions£135.00£135.00Buy on Amazon
HGST HUS726060ALE610 Ultrastar 7K6000 6000 GB InternalHUS726060ALE6106 TBSATAnot sourced£22.50/TBUsedSeller: smart sm solutions£135.00£135.00Buy on Amazon
Toshiba 14TB SATA 512e 256MB Cache 7200RPM 3.5" SATA Enterprise Hard DriveMG07ACA14TE14 TBSATAnot sourced£23.08/TBUsedSeller: Amazon Global Store£323.15£323.15Buy on Amazon
HGST HGST Ultrastar He6 6TB 3.5in SATA 7200 RPM Enterprise Internal Hard Driv...HUS726060ALA6406 TBSATAnot sourced£25.55/TBUsedSeller: Amazon Global Store£153.28£153.28Buy on Amazon
Hitachi HGST WD Ultrastar DC HC510 10TB 7200RPM SATA 3.5-inch SED Hard DriveHUH721010ALE60110 TBSATAnot sourced£25.64/TBUsedSeller: Amazon Global Store£256.42£256.42Buy on Amazon
HGST WD Ultrastar DC HC520 Hard DriveHUH721212ALE60112 TBSATAnot sourced£26.02/TBUsedSeller: Amazon Global Store£312.21£312.21Buy on Amazon
HGST Ultrastar He10HUH721010ALE60010 TBSATAnot sourced£26.07/TBNewSeller: Amazon Global Store£260.69£260.69Buy on Amazon
HGST Ultrastar He12HUH721212ALE60112 TBSATAnot sourced£26.26/TBNewSeller: Amazon Global Store£315.13£315.13Buy on Amazon
HGST HUS726060ALA640 Ultrastar He6HUS726060ALA6406 TBSATAnot sourced£27.06/TBUsedSeller: Amazon Global Store£162.36£162.36Buy on Amazon
HGST Ultrastar 7K6000 HUS726060ALE610HUS726060ALE6106 TBSATAnot sourced£29.84/TBUsedSeller: Amazon Global Store£179.06£179.06Buy on Amazon
Western Digital Ultrastar DC HC5300F3128414 TBSATAnot sourced£32.50/TBNewSeller: Componix Global£455.00£455.00Buy on Amazon
Western Digital Ultrastar DC HC3100B360396 TBSATAnot sourced£33.00/TBUsedSeller: KAH Technologies Ltd£198.00£198.00Buy on Amazon
Western Digital Ultrastar DC HC520HUH721212ALE60412 TBSATAnot sourced£35.83/TBNewSeller: NeMo Laptops£429.99£429.99Buy on Amazon
Seagate ST4000NM0115ST4000NM01154 TBSATAnot sourced£37.50/TBUsedSeller: ServerPartsIT£149.99£149.99Buy on Amazon
Seagate Exos 7E10 4TB Internal Hard Drive HDDST4000NM000B4 TBSATAnot sourced£37.74/TBUsedSeller: Tannas LTD£150.94£150.94Buy on Amazon
Western Digital Hitachi HDD Int 10TB Ultrastar 72 SATA 3.5 HUH721010ALE604HUH721010ALE60410 TBSATAnot sourced£38.24/TBNewSeller: 88 TECH co uk£382.38£382.38Buy on Amazon
Western Digital HDD Gold 12 TB SATA 256 MBWD121KRYZ12 TBSATAnot sourced£40.00/TBUsedSeller: smart sm solutions£480.00£480.00Buy on Amazon
Seagate Exos X14 12TB 7200 RPM SATA 256MB Cache 3.5-Inch Enterprise Hard DriveST12000NM000812 TBSATAnot sourced£41.58/TBNewSeller: Primebridge£499.00£499.00Buy on Amazon
Seagate Exos 7E10 10TB Internal Hard Drive HDDST10000NM017B10 TBSATAnot sourced£43.20/TBNewSeller: CUBS Computer Warehouse£431.95£431.95Buy on Amazon
Seagate Enterprise Exos X16 3.5" 12000 GB Serial ATA IIIST12000NM001G12 TBSATAnot sourced£43.75/TBNewSeller: The Full-Cart£525.00£525.00Buy on Amazon
HGST Ultrastar HUS724040ALE640HUS724040ALE6404 TBSATAnot sourced£44.75/TBUsedSeller: KAH Technologies Ltd£179.00£179.00Buy on Amazon
Western Digital Ultrastar DC HC310 HUS726T4TALE6L4 3.5" 4000 GB Serial ATA III0B360404 TBSATAnot sourced£45.00/TBUsedSeller: smart sm solutions£180.00£180.00Buy on Amazon
Seagate Exos 7E10 2TB Internal Hard Drive HDDST2000NM000B2 TBSATAnot sourced£45.00/TBUsedSeller: Compuclear£89.99£89.99Buy on Amazon
Seagate Exos 7E10 8TB Internal Hard Drive HDDST8000NM017B8 TBSATAnot sourced£45.33/TBNewSeller: PCBOOST£362.64£362.64Buy on Amazon

n/s = we could not read that value from the listing. Prices are in pounds sterling and include VAT.

2.5-inch SAS drives for the ML350 Gen10 SFF cages

An SFF build takes 2.5-inch drives in its hot-plug cages. HPE's SFF example of 48 TB uses 2 TB drives. The table shows 21 listings right now.

2.5-inch SAS enterprise drives up to 14 TB on Amazon.co.uk, lowest £/TB first

Product
Part number
Capacity
Interface
Recording
£/TB inc VAT
Condition
Price (inc VAT)
Buy on Amazon
Seagate Exos 7E2000 HDD 2.5 1TB SAS 7.2K 128MBST1000NX03731 TBSASnot sourced£64.32/TBNewSeller: YUMEZ£64.32£64.32Buy on Amazon
Seagate Enterprise Performance 10K HDD ST600MM0006 600 GB Internal Hard DriveST600MM00060.6 TBSASnot sourced£65.08/TBNewSeller: 88 TECH co uk£39.05£39.05Buy on Amazon
Seagate Savvio 10K.6 600GB 600GB SAS Hard DriveST600MM00060.6 TBSASnot sourced£71.77/TBNewSeller: 88 TECH co uk£43.06£43.06Buy on Amazon
Seagate Enterprise Performance 10K.9 1200GB SAS Hard DriveST1200MM00091.2 TBSASnot sourced£87.50/TBNewSeller: Tech Genious Ltd£105.00£105.00Buy on Amazon
Seagate Enterprise Performance 0.9 TBST9900805SS0.9 TBSASnot sourced£92.77/TBNewSeller: HYT GLOBAL£83.49£83.49Buy on Amazon
Seagate Exos 10E2400 ST1200MM0009ST1200MM00091.2 TBSASnot sourced£100.00/TBNewSeller: Tech Genious Ltd£120.00£120.00Buy on Amazon
Seagate Exos 1.2TB SAS10K 512n 128MBST1200MM00091.2 TBSASnot sourced£100.00/TBNewSeller: Tech Genious Ltd£120.00£120.00Buy on Amazon
Seagate Exos 10E2400 ST1200MM0129 1.2TBST1200MM01291.2 TBSASnot sourced£148.50/TBNewSeller: 88 TECH co uk£178.20£178.20Buy on Amazon
Seagate Exos 7E2000 ST1000NX0453ST1000NX04531 TBSASnot sourced£175.00/TBNewSeller: smart sm solutions£175.00£175.00Buy on Amazon
Seagate Exos 600GB SAS10K 512n 128MbSGT-ST600MM00090.6 TBSASnot sourced£236.57/TBNewSeller: 88 TECH co uk£141.94£141.94Buy on Amazon
Seagate Savvio 10K.5 ST9300605SS Internal Hard Drive 300 GB /ST9300605SS0.3 TBSASnot sourced£236.67/TBNewSeller: SURPLUSDRIVESUK LTD£71.00£71.00Buy on Amazon
Seagate Exos 15E900 ST600MP0006ST600MP00060.6 TBSASnot sourced£270.00/TBNewSeller: Tech Genious Ltd£162.00£162.00Buy on Amazon
Seagate Enterprise Performance 15K HDD ST600MP0005 600 GB Internal Hard DriveST600MP00050.6 TBSASnot sourced£291.67/TBNewSeller: smart sm solutions£175.00£175.00Buy on Amazon
Seagate Enterprise Performance 10K HDD ST300MM0006 300 GB Internal Hard DriveST300MM00060.3 TBSASnot sourced£310.83/TBNewSeller: SURPLUSDRIVESUK LTD£93.25£93.25Buy on Amazon
Seagate Savvio 300GB SAS 300GB SAS Hard DriveST9300653SS0.3 TBSASnot sourced£316.67/TBNewSeller: SURPLUSDRIVESUK LTD£95.00£95.00Buy on Amazon
Seagate Enterprise Performance 15K HDD ST300MP0005 300 GB Internal Hard DriveST300MP00050.3 TBSASnot sourced£316.97/TBNewSeller: 88 TECH co uk£95.09£95.09Buy on Amazon
Seagate Exos 300GB E-Class Mission Critical 2.5"" 10K SAS Hard DriveST300MM00480.3 TBSASnot sourced£352.87/TBNewSeller: 88 TECH co uk£105.86£105.86Buy on Amazon
Seagate Exos 15E900 ST600MP0136ST600MP01360.6 TBSASnot sourced£391.67/TBNewSeller: LOGICFIX LTD£235.00£235.00Buy on Amazon
Seagate Exos 15E900 ST600MP0136 600GB Internal 2.5" SFF SAS 15000rpm 256MB B...ST600MP01360.6 TBSASnot sourced£410.92/TBNewSeller: 88 TECH co uk£246.55£246.55Buy on Amazon
Seagate Exos 15E900 ST300MP0006ST300MP00060.3 TBSASnot sourced£414.00/TBNewSeller: 88 TECH co uk£124.20£124.20Buy on Amazon
Seagate Enterprise Performance 15 K 900GB HDD 4 K native/512 Emulation 15000R...ST900MP01460.9 TBSASnot sourced£420.27/TBNewSeller: 88 TECH co uk£378.24£378.24Buy on Amazon

n/s = we could not read that value from the listing. Prices are in pounds sterling and include VAT.

New and used offers appear together, labelled row by row. Size and interface put a drive in these tables; HPE qualification is a separate matter. If the Recording cell is empty, we hold no maker document naming that part number. The SAS vs SATA page sets out what the interface changes, and used server hard drives covers drives that have already seen service.

HPE option part numbers sold on Amazon.co.uk

A handful of listings sell HPE-branded drives under -B21 option numbers. The table below lists any in stock, by price; it is empty otherwise.

HPE -B21 option drives and SSDs on Amazon.co.uk, lowest price first

Product
Part number
Capacity
Interface
£/TB inc VAT
Condition
Price (inc VAT)
Buy on Amazon
HP 653950-001 146GB 6G SAS 15K RPM SFF652605-B21n/sSAS-UsedSeller: ServerPartsIT£99.99£99.99Buy on Amazon
HP 781518-B21 Enterprise781518-B211.2 TBSAS£133.33/TBUsedSeller: ServerPartsIT£159.99£159.99Buy on Amazon
Hewlett Packard Enterprise"875503-b21 240go 2.5" Serial ATA III Solid State D...875503-B21n/sSATA-UsedSeller: ServerPartsIT£185.62£185.62Buy on Amazon
HP 1.2TB 12G SAS 10K 2.5in SC ENT HDD 781518-B21781518-B211.2 TBSAS£174.99/TBUsedSeller: ServerPartsIT£209.99£209.99Buy on Amazon
Hewlett Packard Enterprise 873351-B21 400GB 2.5" SAS Solid State Drive873351-B21n/sSAS-UsedSeller: ServerPartsIT£629.99£629.99Buy on Amazon

n/s = we could not read that value from the listing. Prices are in pounds sterling and include VAT.

FeatureKindHPE QuickSpecs entry
834031-B21LFF hard drive8 TB SAS 12G Midline 7.2K, LP, 512e
881781-B21LFF hard drive12 TB SAS 12G Midline 7.2K, LP, helium, 512e
873351-B21SFF SSD400 GB SAS 12G, write intensive
875503-B21SFF SSD240 GB SATA 6G, read intensive
P06200-B21SFF SSD3.84 TB SATA 6G, read intensive

An SFF ML350 owner will look first at the three SSDs. HPE's SSD QuickSpecs put Gen9 & 10 in their Server Gen Supported (Select Platforms) column, a statement about generations rather than about the ML350 Gen10. No HPE document we have found ties 834031-B21 or 881781-B21 to a server model; your own server's QuickSpecs is the place to check those. The three option documents behind this table are third-party copies, two on jarcomputers.com and one on router-switch.com. See HPE ProLiant hard drives for more HPE options, and HP DL380 Gen9 for another ProLiant.

Frequently asked questions

Can I put a SAS drive in an ML350 Gen10 with non-hot-plug bays?

No. HPE's QuickSpecs restrict the non-hot-plug LFF version to SATA hard disk drives.

How many drives does an HPE ML350 Gen10 hold?

Up to 24 SFF drives with the hot-plug SFF cages, or up to 12 LFF drives once a 4 LFF chassis has its cage kits.

Does an HPE ProLiant ML350 Gen10 hard drive come with the server?

No. HPE's QuickSpecs say none ship standard.

Sources

  1. HPE: HPE ProLiant ML350 Gen10 Server QuickSpecs (document a00021852enus, marked RETIRED; version history 14, 3 June 2019), accessed 9 November 2026
  2. HPE (copy hosted by jarcomputers.com): HPE Hard Disk Drives QuickSpecs, accessed 9 November 2026
  3. HPE (copy hosted by router-switch.com): HPE Hard Disk Drives datasheet, accessed 9 November 2026
  4. HPE (copy hosted by jarcomputers.com): HPE Solid State Disk Drives QuickSpecs, accessed 9 November 2026